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Financement de l’UE (5 997 381 €) : Mécanismes causaux et modèles intégratifs liant le stress précoce à la multimorbidité psycho-cardio-métabolique Hor01/01/2020 Programme de recherche et d'innovation de l'UE « Horizon »
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Mécanismes causaux et modèles intégratifs liant le stress précoce à la multimorbidité psycho-cardio-métabolique
EarlyCause will identify and demonstrate causative mechanisms and molecular pathways linking early life stress (ELS) to depression and two of its main physical comorbidities, namely coronary heart disease and diabetes. The consortium will disentangle the complex biological contributions from four key interconnected domains linked to ELS, namely epigenetics, inflammation, neuroendocrine system, and microbiome. Furthermore, modifying effects of environmental factors such as sex/gender, socioeconomics, lifestyle and behavior will be quantified, thus uncovering potential intervention targets that may reverse the causative mechanisms and reduce the impact of ELS on multi-morbidity development in high-risk individuals. To achieve the goals of the project, this highly multi-disciplinary and experienced consortium will combine state-of-the-art and novel approaches from basic, pre-clinical and clinical research, including causal inference methods such as Mendelian randomisation, animal models of prenatal and postnatal stress, cellular models in various tissues, and integrative bioinformatics and machine learning methods. The consortium members will also enable access and exploitation of the largest set of European cohorts, comprising rich information on early stressors, biological and omics data, as well as depressive, cardiovascular and metabolic phenotypes. Generated data, tissue samples, experimental protocols and cell lines, as well as best practices, will be compiled and integrated into a new open-access research platform within ELIXIR to support future researchers in the emerging topics of ELS and multi-morbidity. Finally, the project will ensure the research, clinical and socioeconomic impacts are adequately quantified and translated to allow full exploitation of the identified biomarkers and innovation outputs, in particular in relation to new integrated care pathways taking into account ELS-induced multi-morbidity in clinical practice.
| Agencia Estatal Consejo Superior de Investigaciones Cientificas | 398 428 € |
| COMBINOSTICS Oy | 30 563 € |
| Centre Europeen de Recherche en Biologie et Medecine | 323 125 € |
| EMPIRICA GESELLSCHAFT für KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG mbH | 430 625 € |
| 502 950 € | |
| Erasmus Universitair Medisch Centrum Rotterdam | 551 250 € |
| King's College London | 554 404 € |
| OULUN YLIOPISTO | 508 000 € |
| 320 950 € | |
| Stichting Amsterdam UMC | 419 080 € |
| 581 250 € | |
| 70 938 € | |
| Universita Degli Studi DI Milano | 0,00 € |
| Universitat de Barcelona | 887 156 € |
| University of Bath | 418 664 € |
https://cordis.europa.eu/project/id/848158
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