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Financement de l’UE (8 181 676 €) : Développer l’utilisation industrielle des biocatalyseurs oxydatifs robustes pour la conversion et la production d’alcools (ROBOX) Hor01/04/2015 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Développer l’utilisation industrielle des biocatalyseurs oxydatifs robustes pour la conversion et la production d’alcools (ROBOX)
Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> €1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency. In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants. ROBOX is industry-driven with 2 major industrial players and 6 SME’s. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, “plug bug” expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).
| Acib GmbH | 282 279 € |
| C-LECTA GmbH | 274 952 € |
| Chemstream BVBA | 298 813 € |
| DSM Food Specialties B.V. | 0,00 € |
| 0,00 € | |
| Danmarks Tekniske Universitet | 705 259 € |
| 89 578 € | |
| EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH | 0,00 € |
| EVOXX TECHNOLOGIES GmbH | 312 025 € |
| FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG e. V. | 211 232 € |
| GIVAUDAN SUISSE SA | 0,00 € |
| Genencor International B.V. | 265 759 € |
| Innosyn B.V. | 478 363 € |
| Koninklijke DSM N.V. | 0,00 € |
| LentiKat'SAS | 55 810 € |
| 97 370 € | |
| PNO Innovation | 0,00 € |
| RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN | 741 419 € |
| Rijksuniversiteit Groningen | 1 062 896 € |
| Technische Universitaet Graz | 675 415 € |
| The University of Manchester | 472 391 € |
| Universita Degli Studi DI Pavia | 447 205 € |
| Universitat Autonoma de Barcelona | 489 783 € |
| Universiteit Maastricht | 458 296 € |
https://cordis.europa.eu/project/id/635734
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