Moteur de recherche d’entreprises européennes
Financement de l’UE (185 076 €) : Interaction entre le microbiote intestinal et le système central de stress dans les altérations cognitives associées au vieillissement. Hor08/04/2016 Programme de recherche et d'innovation de l'UE « Horizon »
Vue d’ensemble
Texte
Interaction entre le microbiote intestinal et le système central de stress dans les altérations cognitives associées au vieillissement.
Aging drives cognitive impairment and general health demise increasing the susceptibility to neurodegenerative disorders in healthy individuals. It is also associated with changes in the gut-microbiota and a general increase in the secretion of stress hormones, known to have debilitating effects when sustained. The gut-microbiota has recently emerged has a crucial modulator of cognitive abilities and general health. Nonetheless, the causes and consequences of the gut-microbiota changes seen in aging are currently unknown. In this application, we propose to study the importance of the age-associated gut-microbiota changes on brain functions, by swapping the gut-microbiota from aged mice into young mice and vice-versa. This will allow knowing the contribution of the gut-microbiota in the cognitive decline and depressive state associated with aging. Furthermore, we will test if the increase in stress hormones known to occur during aging are upstream of those age-associated microbiota changes, by testing the involvement of the amygdala to the hypothalamus-adrenal axis in this phenomena. This will be achieved by using a chemo-genetic approach to control the activation of each component of this pathway. This project will provide the first description of the functional repercussions of the age-associated changes in the gut-microbiota composition on learning and memory deficits and depression, and possibly elucidate one of the upstream mechanisms responsible. The outcome of this work will pave the way toward the elaboration of probiotic treatments against the detrimental effect of aging.
| Institut Pasteur | 185 076 € |
https://cordis.europa.eu/project/id/708466
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : Societe Francophone de Medecine Tropicale et Sante Internationale, Paris.
Les visualisations de "Institut Pasteur - Financement de l’UE (185 076 €) : Interaction entre le microbiote intestinal et le système central de stress dans les altérations cognitives associées au vieillissement."
sont mis à disposition par
North Data
et peuvent être réutilisées selon les termes de la licence
Creative Commons CC-BY.
