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UK funding (171 680 £) : Cellular and genetic models of inherited cystic kidney disease Ukri01/09/2009 UK Research and Innovation, Royaume Uni
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Cellular and genetic models of inherited cystic kidney disease
| Abstract | Cystic kidney disease comprises a group of inherited disorders leading to kidney failure. Cystic kidney disease accounts for 10% of the 40,000 UK patients requiring renal replacement therapy (dialysis and transplantation). Current treatment of cystic kidney disease is supportive rather than preventing disease progression. A better understanding of the disease processes involved is required and experimental models will enable new drugs to be tested. Recently some of the genes mutated in the childhood cystic kidney disease called nephronophthisis have been found. The genes code for proteins called nephrocystins, which have important roles in how the kidney tubules form and orientate themselves. Before cysts develop, patients are unable to concentrate their urine, providing a useful hint that affected kidney cells cannot function at a molecular level. We will investigate, using kidney cells in culture and developing zebrafish where these proteins are located and how they interact to control water reabsorption. In these model systems we will mimic the human disease of nephronophthisis, to determine the underlying processes which lead to cyst formation and evaluate certain drugs which may be important is slowing down this disease. |
| Category | Fellowship |
| Reference | RCS G0802359 |
| Status | Closed |
| Funded period start | 01/09/2009 |
| Funded period end | 31/12/2011 |
| Funded value | £171 680,00 |
| Source | https://gtr.ukri.org/projects?ref=G0802359 |
Participating Organisations
| Newcastle University | |
| University of Leeds | |
| University of Sheffield |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University OF Newcastle Upon Tyne CHARITY, Newcastle upon Tyne, Royaume Uni.
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