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UK funding (330 471 £) : Etudes des processus cellulaires impliqués dans le contrôle de la signalisation des nutriments et leur pertinence pour le vieillissement Ukri15/05/2012 UK Research and Innovation, Royaume Uni
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Etudes des processus cellulaires impliqués dans le contrôle de la signalisation des nutriments et leur pertinence pour le vieillissement
| Abstract | The dramatic increase of human life expectancy and the evidence from laboratory animal models suggest that the lifespan might not have a defined limit. Currently, the best-known means to slow down ageing and to extend the life of laboratory models are dietary restriction or treatments that mimic starvation. The opposite is also true and an excessive calorie intake, characteristic of the contemporary diet in the developed world, contributes to life shortening by promoting age-related diseases including diabetes, cancer and brain dysfunction. While cellular response to nutrients is infinitely complex and involves a myriad of proteins and pathways, the master coordinator of the response is a signalling pathway called mTOR. This is evident from the fact that inhibition of this pathway by drugs is sufficient to induce a starvation-like response in the presence of nutrients. mTOR acts by promoting cellular synthetic processes, such as metabolism, protein synthesis and cell growth, with reducing degradative capacity of the cellular "self-eating" pathway called autophagy. Many of these processes have been shown to be relevant to ageing and inhibition of mTOR dramatically extends lifespan of every laboratory model from yeast to mice. Therefore, increasing our knowledge of how mTOR is regulated will provide us with better chances to fight age-related diseases and potentially to extend human lifespan in the future. The proposed project will investigate cellular processes leading to mTOR activation in response to nutrients and will potentially discover the means to control these processes independently of nutrient availability. We will employ a range of molecular techniques, both in vitro and in the fruit fly, which is a powerful laboratory model best equipped for the proposed work. This integrative approach will allow identification of relevant players on the molecular level and will simultaneously test their role in physiological responses at the organismal level. The outcomes of the research will make a major contribution to our understanding of the fundamental mechanisms underlying cellular nutrient response and will be of wide interest to researchers in the fields of cell signalling, protein degradation, metabolism and ageing. The findings will also potentially inform more applied research aimed towards developing new strategies to combat age-related diseases and to extend lifespan, which would have important implications for medicine. |
| Category | Research Grant |
| Reference | BB/J007803/1 |
| Status | Closed |
| Funded period start | 15/05/2012 |
| Funded period end | 14/05/2015 |
| Funded value | £330 471,00 |
| Source | https://gtr.ukri.org/projects?ref=BB%2FJ007803%2F1 |
Participating Organisations
| Newcastle University | |
| University of Groningen | |
| Whitehead Institute for Biomedical Research | |
| University of Tromsoe | |
| Cardiff University | |
| University of Toulouse |
Cette annonce se réfère à une date antérieure et ne reflète pas nécessairement l’état actuel. L’état actuel est présenté à la page suivante : University OF Newcastle Upon Tyne CHARITY, Newcastle upon Tyne, Royaume Uni.
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